FORMULATION DEVELOPMENT AND EVALUATION OF SITE SPECIFIC PERIODONTAL GELS

Periodontal pockets act as a natural reservoir filled with gingival crevicular fluid for the controlled release of antimicrobials directly. This work reflects present status nonsurgical local intrapocket delivery in treatment periodontitis. These sites have specialty terms anatomy, permeability and their ability to retain system desired length time. A number antimicrobial products composition systems, its use, clinical results, are summarized. In study development site specific periodontal drug was developed Metronidazole Minocycline HCl. is an important active substance that has been widely used some protozoal anaerobic bacterial infections. hydrochloride semi synthetic tetracycline, which primarily indicated Acne vulgaris. Polarizing photographs gel lacking CMC, PVP encircling 10% CMC 5% naked. Photographs demonstrated dark background instance plain gel, though fan like formations were supposed polarizing photograph P5C10 formulation. The consequence drug(s) concentration on gelation melting done. temperature miserable company conical linearly growing concentration, while amended drug(s). mechanical properties augmented formulations supervision disease resolute.